Identification of antitumour activity of novel derivatives of 8-aryl-2,6,7,8-tetrahydroimidazo[2,1-c][1,2,4]triazine-3,4-dione and 8-aryl-4-imino-2,3,7,8-tetrahydroimidazo[2,1-c][1,2,4]triazin-3(6H)-one
- 作者：Krzysztof Sztanke ; Kazimierz Pasternak ; Jolanta Rzymowska ; Mał ; gorzata Sztanke ; Martyna K ; efer-Szerszeń ; Izabela Dybał ; a ; Anna E. Kozioł
- 关键词：8-Aryl-2 ; 6 ; 7 ; 8-tetrahydroimidazo[2 ; 1-c][1 ; 2 ; 4]triazine-3 ; 4-diones ; A novel DNA strand breaking agent ; Crystal structure ; 8-Aryl-4-imino-2 ; 3 ; 7 ; 8-tetrahydroimidazo[2 ; 1-c][1 ; 2 ; 4]triazin-3(6H)-ones ; Anticancer activity ; 1-Aryl-2-hydrazono
- 刊名：Bioorganic and Medicinal Chemistry
- 出版年：2007
- 期刊代码：9_09680896
- 类别：ch
- 出版时间：15 April 2007
- 卷：15
- 期：8
- 页码：2837-2849
- 文件大小：282 K
摘要
The series of 8-aryl-2,6,7,8-tetrahydroimidazo[2,1-c][1,2,4]triazine-3,4-diones (11–20) and 8-aryl-4-imino-2,3,7,8-tetrahydroimidazo[2,1-c][1,2,4]triazin-3(6H)-ones (21–25) were designed and their in vitro cytotoxic activities against human LS180, HeLa, T47D, A549 and RPMI 8226 carcinoma cells are presented. In the crystalline state molecule 12 exists as the predominant tautomeric 3-oxo form, whereas the second possible 3-hydroxy tautomer is not observed. Compound 19 revealed a strong affection to LS180 cancer cells at lower tested concentration (37.9 μM) and simultaneously was found to be non-toxic towards the normal cell line investigated—GMK cells. Furthermore, this compound was proved to possess the efficiency for DNA strand breakage of the examined cancer cell lines. However, imidazotriazin-3,4-dione 20 was able to cause significant viability decreases in human RPMI 8226 peripheral blood myeloma cells. Compound 22 has exhibited remarkable inhibitory effects against LS180 and A549 carcinoma cells, whereas 24 revealed the highest growth inhibition against A549 cell line. Simultaneously, at lower tested concentration these compounds were proved to be completely non-toxic for GMK cells. Moreover, cytotoxic and antibacterial properties of starting, tautomeric 1-aryl-2-hydrazonoimidazolidines (1–6 and 8–9) are presented. Six of them (1–2, 4–6 and 9) proved active as antimicrobials. All these compounds revealed MIC values in the range of 15.0–78.6 μM. Their activities were compared to those of ampicillin and chloramphenicol.