The synthesis and development of 2,5-disubstituted tetrahydrofurans as potential scaffolds for diversity-oriented synthesis

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• 作者：Adrian P. Dobbs ; ^{a.dobbs@qmul.ac.uk} ; Jonathan Dunn
• 关键词：Silylmethylcyclopropane ; Donor cyclopropane ; 2 ; 5-Disubstituted tetrahydrofuran ; Flemming oxidation
• 刊名：Tetrahedron Letters
• 出版年：2012
• 期刊代码：109_00404039
• 类别：ch
• 出版时间：9 May, 2012
• 卷：53
• 期：19
• 页码：2392-2395
• 文件大小：685 K

摘要

The synthesis of 2,5-disubstituted tetrahydrofurans from donor silylmethylcyclopropanes (without bearing an acceptor function) is described. Their further elaboration via a wide range of synthetic transformations is presented to highlight the potential of this method and the resulting THFs as potential scaffolds for diversity-oriented synthesis.