Different manufacturers of syringes: A new source of variability in blood gas, acid-base balance and related laboratory test?

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• 作者：Gabriel Lima-Oliveira^a ; ^b ; ^c ; ^d ; ^{dr.g.lima.oliveira@gmail.com} ; Giuseppe Lippi^e ; Gian Luca Salvagno^a ; Martina Montagnana^a ; Geraldo Picheth^b ; Gian Cesare Guidi^a ; ^b
• 关键词：Blood specimen collection ; Blood gas ; Heparin ; Intensive care unit ; ISO 15189 ; Preanalytical variability ; Syringe
• 出版年：2012
• 期刊代码：55_00099120
• 类别：med
• 出版时间：June, 2012
• 卷：45
• 期：9
• 页码：683-687
• 文件大小：177 K

摘要

Objective

Evaluate whether four different brands/types of heparin coated syringes can represent a source of variability in blood gas analysis (BGA).

Design and methods

Blood was collected from one hundred volunteers into different syringes: Syringe I (lithium heparin and calcium balanced); Syringe II: in-house prepared (sodium heparin); Syringe III: (spray-dried calcium-balanced lithium heparin); Syringe IV (lyophilized electrolyte-balanced lithium heparin).

Results

Significant differences were as follows: a) Syringe I vs II: pO₂, sO₂, pCO₂^t, cHCO₃^{鈭?/sup>, ctCO₂, base excess (BE), total hemoglobin (tHb), sodium (Na+), potassium (K+), calcium (Ca2+), glucose (Glu), lactate (Lac), O₂ Hb and p 50; b) Syringe I vs III: pH, pO₂, cHCO₃鈭?/sup>, ctCO₂, BE, Na+, Glu, Lac and p 50; c) Syringe I vs IV: pH, pO₂, sO₂, pCO₂t, BE, Na+, K+, Ca2+, Glu, Lac and O₂ Hb; d) Syringe II vs III: pH, pO₂, sO₂, pCO₂t, cHCO₃鈭?/sup>, ctCO₂, ctO₂, tHb, Na+, K+, Ca2+, Lac and p 50; e) Syringe II vs IV: pH, pO₂, sO₂, pCO₂t, cHCO₃鈭?/sup>, ctCO₂, BE, tHb, Na+, K+, Ca2+, Lac, O₂ Hb and p 50; f) Syringe III vs IV: pH, pO₂, sO₂, cHCO₃鈭?/sup>, ctCO₂, ctO₂, BE, Na+, K+, Ca2+, O₂ Hb and p 50.}

Conclusion

The different manufacturers of syringes can represent new source of variability on BGA.