Theory of mind impairment in adult-onset myotonic dystrophy type 1

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• 作者：Mutsutaka Kobayakawa^a ; ^b ; ^{kobayakawa@med.showa-u.ac.jp} ; Natsuko Tsuruya^b ; ^c ; ^{ntsuruya@med.showa-u.ac.jp} ; Mitsuru Kawamura^b ; ^{kawa@med.showa-u.ac.jp}
• 关键词：DM 1 ; myotonic dystrophy type 1 ; ToM ; theory of mind ; RMET ; Reading the Mind in the Eyes ; MIRS ; muscular impairment rating scale ; MMSE ; Mini-Mental State Examination ; FAB ; frontal assessment battery ; SDS ; Zung Self-Rating Depression Scale
• 刊名：Neuroscience Research
• 出版年：2012
• 期刊代码：53_01680102
• 类别：neu
• 出版时间：April, 2012
• 卷：72
• 期：4
• 页码：341-346
• 文件大小：254 K

摘要

Patients with myotonic dystrophy type 1 (DM 1) exhibit behavioral disorders and distinctive personality traits. We hypothesize that this is due to altered social cognitive function. To investigate the cognitive basis of this impairment in DM 1 patients, we examined their theory of mind (ToM) ability, which is the specific cognitive ability to understand the mental states of others. Nine adult-onset DM 1 patients (4 men and 5 women) performed 2 ToM tasks: 鈥淩eading the Mind in the Eyes鈥?test and faux pas recognition test. DM 1 patients were found to be impaired in both ToM tests, but had no difficulty with control tasks designed to test visual and lexical comprehension. The present results indicate that social cognitive impairment in patients with adult-onset DM 1 is associated with ToM dysfunction, which could be due to the brain lesions associated with this disease.