Inhibition of virus-induced age-dependent poliomyelitis by interferon-γ
- 作者：Cafruny ; William A. ; Haven ; Thomas R. ; Lawson ; Steven R. ; Wong ; Grace H.W. ; Rowland ; Raymond R.R.
- 关键词：Age-dependent poliomyelitis ; Lactate dehydrogenase-elevating virus ; Interferon-γ
- 刊名：Antiviral Research
- 出版年：1997
- 期刊代码：7_01663542
- 类别：imm
- 出版时间：October, 1997
- 卷：36
- 期：1
- 页码：1-9
- 文件大小：742 K
摘要
Age-dependent poliomyelitis (ADPM) is a neuroparolytic disease which results from combined infection of susceptible mice with lactate dehydrogenase-elevating virus (LDV) and murine leukemia virus (MuLV). The present study examined the effects of interferon-b3; (IFN-b3;) treatment on the incidence of ADPM, replication of LDV and MuLV and anti-LDV immunity. IFN-b3; treatment of ADPM-susceptible C58/M mice protected them from paralytic disease, but had no detectable effect on the IgG anti-LDV response or LDV viremia. IFN-b3;-mediated protection from ADPM correlated with reduced expression of LDV RNA, but not MuLV RNA, in the spinal cords of C58/M mice. These results confirm that spinal cord LDV replication is the determinant of ADPM and demonstrate that cytokine-mediated inhibition of LDV replication in the central nervous system prevents neuroparalytic disease.