Translocation (1;19)(q21;q13.3) is a recurrent reciprocal translocation in meningioma

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• 作者：Sawyer ; Jeffrey R. ; Thomas ; Edward L. ; Al-Mefty ; Ossama
• 刊名：Cancer Genetics and Cytogenetics
• 出版年：2002
• 期刊代码：43_01654608
• 类别：med
• 出版时间：April 1, 2002
• 卷：134
• 期：1
• 页码：88-90
• 文件大小：71.1 K

摘要

Benign meningiomas are characterized by a normal karyotype or loss of all or part of chromosome 22. Histologically higher grade tumors are typically characterized by a pattern of increasing chromosome loss and instability. This characteristic pattern of unbalanced chromosome aberrations is punctuated in the literature by several intriguing reports of a reciprocal t(1;19)(q21;q13.3) as the sole cytogenetic aberration. We report a third case showing the t(1;19)(q21;q13.3) with additional unstable secondary aberrations of a dic(18;22)(p11;p11) and telomeric fusions.