Loss of intestinal fatty acid binding protein increases the susceptibility of male mice to high fat diet-induced fatty liver

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• 作者：Luis B. Agellon ; Laurie Drozdowski ; Lena Li ; Claudiu Iordache ; Le Luong ; M. Tom Cl ; inin ; Richard R.E. Uwiera ; Matthew J. Toth ; Alan B.R. Thomson
• 关键词：FABP ; High fat diet ; Fatty liver ; Small intestine ; Mouse ; Gender effect
• 刊名：Biochimica et Biophysica Acta (BBA)/Molecular and Cell Biology of Lipids
• 出版年：2007
• 期刊代码：18_13881981
• 类别：bio
• 出版时间：October 2007
• 卷：1771
• 期：10
• 页码：1283-1288
• 文件大小：343 K

摘要

Mice lacking I-FABP (encoded by the Fabp2 gene) exhibit a gender dimorphic response to a high fat/cholesterol diet challenge characterized by hepatomegaly in male I-FABP-deficient mice. In this study, we determined if this gender-specific modification of liver mass in mice lacking I-FABP is attributable to the high fat content of the diet alone and whether hepatic Fabp1 gene (encodes L-FABP) expression contributes to this difference. Wild-type and Fabp2^−/− mice of both genders were fed a diet enriched with either polyunsaturated or saturated fatty acids (PUFA or SFA, respectively) in the absence of cholesterol. Male Fabp2^−/− mice, but not female Fabp2^−/− mice, exhibited increased liver mass and hepatic triacylglycerol (TG) deposition as compared to corresponding wild-type mice. In wild-type mice that were fed the standard chow diet, there was no difference in the concentration of hepatic L-FABP protein between males and females although the loss of I-FABP did cause a slight reduction of hepatic L-FABP abundance in both genders. The hepatic L-FABP mRNA abundance in both male and female wild-type and Fabp2^−/− mice was higher in the PUFA-fed group than in the SFA-fed group, and was correlated with L-FABP protein abundance. No correlation between hepatic L-FABP protein abundance and hepatic TG concentration was found. The results obtained demonstrate that loss of I-FABP renders male mice sensitive to high fat diet-induced fatty liver, and this effect is independent of hepatic L-FABP.