TAT-BH4 counteracts Ab2; toxicity on capillary endothelium

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• 作者：S. Cantara ; P.E. Thorpe ; M. Ziche ; S. Donnini
• 关键词：Beta amyloid ; Endothelium ; TAT-BH4 ; Apoptosis ; Cerebral amyloid angiopathy
• 刊名：FEBS Letters
• 出版年：2007
• 期刊代码：70_00145793
• 类别：bio
• 出版时间：20 February 2007
• 卷：581
• 期：4
• 页码：702-706
• 文件大小：480 K

摘要

Oxidative stress is one of the factor contributing to blood brain barrier degeneration. This phenomenon is observed during pathological conditions such as Alzheimer’s disease or cerebral amyloid angiopathy in which brain haemorrhages are very frequent. Both diseases are characterized by beta amyloid peptide deposition either in neurons or in vessels. Oxidative stress leads to impairment of mitochondrial functions and apoptotic cell death subsequent to caspases activation. In this paper we demonstrate that BH4 domain of Bcl-xl administrated to endothelial cells as the conjugated form with TAT peptide, reverts Ab2;-induced apoptotic cell death by activating a survival programme which is Akt/endothelial nitric oxide synthase dependent.