Cross-sectional associations of C-reactive protein with vascular risk factors and vascular complications in the DCCT/EDIC cohort

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• 作者：Alicia J. Jenkins ; Michelle Rothen ; Richard L. Klein ; Karina Moller ; Leslie Eldridge ; Deyi Zheng ; Ramon Durazo-Arvizu ; Daniel McGee ; Daniel Lackl ; Suzanne R. Thorpe ; W. Timothy Garvey ; Timothy J. Lyo
• 关键词：Type 1 diabetes ; C-Reactive protein ; Inflammation ; Complications
• 刊名：Journal of Diabetes and its Complications
• 出版年：2008
• 期刊代码：154_10568727
• 类别：med
• 出版时间：May-June 2008
• 卷：22
• 期：3
• 页码：153-163
• 文件大小：457 K

摘要

In a community-based group of Japanese elderly (n = 689), CRP concentrations were measured using a highly sensitive assay. All participants underwent magnetic resonance imaging (MRI), and cerebral small vessel disease-related lesions (lacunar infarcts and white matter hyperintensity) were subsequently evaluated. Furthermore, carotid atherosclerosis was also assessed with ultrasonography. As the grades of white matter hyperintensity and the numbers of lacunes were considered small vessel disease-related lesions, we evaluated the relationships between CRP levels and small vessel disease-related brain lesions. Interestingly, the median CRP concentration of our participants was remarkably lower, being approximately one third or one quarter of the value of Western populations. Subjects with higher CRP levels tended to have more small vessel disease-related lesions; however, these associations were not seen after adjustment for cardiovascular risk factors and carotid atherosclerosis.

Conclusions

The relationship between CRP levels and small vessel disease-related lesions was not apparent in the community-based Japanese elderly. The impact of inflammation in the pathogenesis of small vessel disease-related brain lesions seems to be weak among the Japanese elderly.