Impaired spontaneous thrombolytic activity measured by global thrombosis test in males with metabolic syndrome

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• 作者：Akira Suehiro^a ; ^{asuehiro@huhs.ac.jp} ; Ichiro Wakabayashi^b ; Kagehiro Uchida^c ; Tsutomu Yamashita^d ; Junichiro Yamamoto^e
• 关键词：BP ; blood pressure ; FBS ; fasting blood sugar ; GTT ; global thrombosis test ; HDL-C ; high-density lipoprotein cholesterol ; LT ; lysis time ; MetS ; metabolic syndrome ; OT ; occlusion time ; PAI-1 ; plasminogen activator inhibitor-1 ; TG ; triglyceride
• 刊名：Thrombosis Research
• 出版年：2012
• 期刊代码：247_00493848
• 类别：med
• 出版时间：April, 2012
• 卷：129
• 期：4
• 页码：499-501
• 文件大小：139 K

摘要

Introduction

In patients with metabolic syndrome (MetS), activity of the fibrinolytic system is generally surmised to be decreased through increased plasminogen activator inhibitor-1 (PAI-1) generation. However, there have been no detailed reports describing whether the clot lysis activity is more dominant than increased clot formation activity for production of the thrombotic state in MetS.

Methods

The global thrombosis test (GTT) is a novel method designed to test both clot formation and clot lysis activities under physiological conditions by using non-anticoagulated blood samples in vitro. We used the GTT to examine the thrombotic or thrombolytic states in males with MetS.

Results

Lysis time, which reflects spontaneous clot lysis activity, was significantly longer in MetS subjects (median, 1494 s; range, 865-3596 s; n = 30) than in control subjects (median 1246 s; range, 667-2239 s; n = 53). There was no significant difference between the two groups in occlusion time, which reflects platelet function. The mean level of PAI-1 was significantly higher in MetS subjects than in controls (mean 卤 SE, 8.7 卤 1.1 and 5.0 卤 0.5 ng/mL, respectively). PAI-1 level and lysis time were significantly correlated (r = 0.400, P < 0.01).

Conclusion

These results suggest that male patients with MetS are more likely than controls to experience a thrombotic state through decreased fibrinolytic activity due to increased PAI-1 generation, and that the GTT is useful for evaluating fibrinolytic activity in vitro.