Estrogen activity as a preventive and therapeutic target in thyroid cancer

详细信息	查看全文 | 推荐本文 |

• 作者：Shilpi Rajoria^a ; Robert Suriano^a ; Andrea L. George^a ; Arulkumaran Shanmugam^a ; Casey Jussim^a ; Edward J. Shin^b ; Augustine L. Moscatello^a ; Jan Geliebter^a ; Angelo Carpi^c ; Raj K. Tiwari^a ; ^{raj_tiwari@nymc.edu}
• 关键词：Thyroid proliferative diseases ; Thyroid cancer ; Estrogen ; Antiestrogen ; Estrogen receptor
• 刊名：Biomedicine and Pharmacotherapy
• 出版年：2012
• 期刊代码：36_07533322
• 类别：med
• 出版时间：March, 2012
• 卷：66
• 期：2
• 页码：151-158
• 文件大小：379 K

摘要

Thyroid cancer is the most common endocrine-related cancer with increasing incidences during the last five years. Interestingly, according to the American Thyroid Association, the incidences of thyroid proliferative diseases occur four to five times more in women than in men with the risk of developing thyroid disorders being one in every eight females. Several epidemiological studies have suggested a possible correlation between incidences of thyroid malignancies and hormones but the precise contribution of estrogen in thyroid proliferative disease initiation, and progression is not well understood. This review is an attempt to define the phenotypic and genotypic modulatory effects of estrogen on thyroid proliferative diseases. The significance and relevance of expression of estrogen receptors, 伪 and 尾, in normal and malignant thyroid tissues and their effects on different molecular pathways involved in growth and function of the thyroid gland are discussed. These novel findings open up areas of developing alternative therapeutic treatments and preventive approaches which employ the use of antiestrogen to treat thyroid malignancies.