Impairment in differentiation and cell cycle of thymocytes by loss of a Bcl11b tumor suppressor allele that contributes to leukemogenesis

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• 作者：Rieka Go^a ; Kazuyoshi Takizawa^a ; ^b ; Satoshi Hirose^a ; Yoshinori Katsuragi^a ; Yutaka Aoyagi^b ; Yukio Mishima^a ; Ryo Kominami^a ; ^{rykomina@med.niigata-u.ac.jp}
• 关键词：T-ALL ; BCL11B ; Type B abnormalities ; Haploinsufficiency ; Cell cycle of thymocytes
• 刊名：Leukemia Research
• 出版年：2012
• 期刊代码：186_01452126
• 类别：med
• 出版时间：August, 2012
• 卷：36
• 期：8
• 页码：1035-1040
• 文件大小：885 K

摘要

Genetic changes in T-ALL are classified into type A abnormalities leading to arrest at a specific stage of T-cell differentiation and type B abnormalities that target cellular processes including cell cycle regulation. Mutations and deletion of a BCL11B haploinsuffiecient tumor suppressor allele have been found in 10-16%of T-ALL subgroups. Analysis of Bcl11b^KO/+ mice revealed impaired T-cell differentiation at two different stages and attenuation of 纬-ray induced cell-cycle arrest at S/G2/M phase in immature CD8 single positive cells. Hence, those phenotypes provided by loss of a Bcl11b allele favor that Bcl11b mutation belongs to type B abnormalities.