Differential effects of tannic acid on cisplatin induced nephrotoxicity in rats
- 作者：Kulbhushan Tikoo ; Deepak Kumar Bhatt ; Anil Bhanudas Gaikwad ; Vikram Sharma ; Dhiraj G. Kabra
- 关键词：Cisplatin ; Nephrotoxicity ; poly(ADP-ribose) polymerase ; Histone H4 ; p-p38 and Tannic acid
- 刊名：FEBS Letters
- 出版年：2007
- 期刊代码：70_00145793
- 类别：bio
- 出版时间：15 May 2007
- 卷：581
- 期：10
- 页码：2027-2035
- 文件大小：863 K
摘要
Cisplatin is a widely used antineoplastic drug. Major drawback of cisplatin therapy is its nephrotoxicity. The objective of this study was to check the effect of tannic acid on cisplatin induced nephrotoxicity. Post-treatment of tannic acid prevents cisplatin (5 mg/kg) induced nephrotoxicity and decreases poly(ADP-ribose) polymerase cleavage, phosphorylation of p38 and hypoacetylation of histone H4. In contrast, co-treatment of tannic acid potentiates the nephrotoxicity. Comparative nephrotoxicity studies show that co-treatment of tannic acid with reduced dose of cisplatin (1.5 mg/kg) developed almost similar nephrotoxicity. MALDI protein profiling of plasma samples provides indirect evidence that tannic acid co-treatment increases bioavailability of cisplatin.