Further evidence of an association between adolescent bipolar disorder with smoking and substance use disorders: A controlled study

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• 作者：Timothy E. Wilens ; Joseph Biederman ; Joel J. Adamson ; Aude Henin ; Stephanie Sgambati ; Martin Gignac ; Robert Sawtelle ; Alison Santry ; Michael C. Monuteaux
• 关键词：Adolescent ; Mania ; Bipolar disorder ; Substance abuse
• 刊名：Drug and Alcohol Dependence
• 出版年：2008
• 期刊代码：81_03768716
• 类别：med
• 出版时间：1 June 2008
• 卷：95
• 期：3
• 页码：188-198
• 文件大小：386 K

摘要

Although previous work suggests that juvenile onset bipolar disorder increases risk for substance use disorders and cigarette smoking, the literature on the subject is limited. We evaluated the association of risk for substance use disorders and cigarette smoking with bipolar disorder in adolescents in a case–control study of adolescents with bipolar disorder (n = 105, age 13.6 ± 2.5 years [mean]; 70%male) and without bipolar disorder (“controls”; n = 98, age 13.7 ± 2.1 years; 60%male). Rates of substance use and other disorders were assessed with structured interviews (KSADS-E for subjects younger than 18, SCID for 18-year-old subjects). Bipolar disorder was associated with a significant age-adjusted risk for any substance use disorder (hazard ratio[95%confidence interval] = 8.68[3.02 25.0], χ² = 16.06, p < 0.001, df = 1), alcohol abuse (7.66 [2.20 26.7], χ² = 10.2, p = 0.001, df = 1), drug abuse (18.5 [2.46 139.10], χ² = 8.03, p = 0.005, df = 1) and dependence (12.1 [1.54 95.50], χ² = 5.61, p = 0.02, df = 1), and cigarette smoking (12.3 [2.83 53.69], χ² = 11.2, p < 0.001, df = 1), independently of attention deficit/hyperactivity disorder, multiple anxiety, and conduct disorder (CD). The primary predictor of substance use disorders in bipolar youth was older age (BPD − SUD versus BPD + SUD, logistic regression: χ² = 89.37, p < 0.001). Adolescent bipolar disorder is a significant risk factor for substance use disorders and cigarette smoking, independent of psychiatric comorbidity. Clinicians should carefully screen adolescents with bipolar disorder for substance and cigarette use.