Alzheimer Disease National Cell Repository
- 作者：Conneally ; P.M. ; Fugman ; D. ; Hodes ; M.E. ; Tischfield ; J.
- 刊名：Neurobiology of Aging
- 出版年：1996
- 期刊代码：202_01974580
- 类别：med
- 出版时间：1996
- 卷：17
- 期：4
- 页码：S63
- 文件大小：115 K
摘要
The AD National Cell Repository began in 1989, as a collaboration between Indiana and Duke universities. It was established to provide the research community with large numbers of well characterized, informative families with multiple individuals affected with Alzheimer Disease. The main goal of the Repository is to facilitate research aimed at expanding our understanding of the etiology, pathogenesis, diagnosis, treatment, prevention, and ultimately, potential cure for this disease. The Repository collects and maintains information and biological specimens on well-characterized families with AD in order to provide a resource for use in research projects and to encourage and foster the development of new avenues of AD research. Specifically, the Repository seeks to identify, recruit, gather and maintain information from families with histories of AD. This includes pedigree information; medical records concerning the evaluation, diagnosis, and treatment of patients; documentation of the cognitive, behavioral and social consequences of AD; epidemiological and demographic data, and neuropathological diagnosis information. The data bank has records on 650 families comprising 38,000 individuals. The cell bank has established over 1,600 cell lines. All lines are tested for the presence of mycoplasm contamination. Meticulous care is used to avoid sample mix-up. A bar code system is used in conjunction with the data base to ensure careful tracking of all blood, transformed cells, and DNA samples. A DNA “fingerprint” is generated for all blood samples on arrival which can later be compared with a questionable sample. In conjunction with the collection of these data, the Repository seeks to collect, maintain and distribute DNA and permanent cell lines from these families and to make these samples and corresponding information available for research to qualified investigators throughout the world. The use of common data and sample sets by various researchers employing different approaches is likely to facilitate comparison of data and the emergence of a common understanding of possible interpretations. The inherent control provided by common sample sets is particularly important in research aimed at understanding a disease with significant genetic and phenotypic heterogeneity. To this end, we have already provided over 3,200 samples to nearly 40 researchers throughout the world.