Axonal injury in experimental herpes simplex encephalitis

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• 作者：Isamu Mori ; Fumi Goshima ; Terukazu Mizuno ; Yoshinori Imai ; Shinichi Kohsaka ; Hiroyasu Ito ; Naoki Koide ; Tomoaki Yoshida ; Takashi Yokochi ; Yoshinobu Kimura and Yukihiro Nishiyama
• 关键词：Axonal injury ; β ; -amyloid precursor protein ; Herpes simplex virus ; Encephalitis ; Microglia ; Macrophage
• 刊名：Brain Research
• 出版年：2005
• 期刊代码：8_00068993
• 类别：neu
• 出版时间：2005
• 卷：1057
• 期：1-2
• 页码：186-190
• 文件大小：247 K

摘要

Using β-amyloid precursor protein immunolabeling, we have detected axonal injury in experimental herpes simplex encephalitis. β-amyloid precursor protein-specific signals were found in the mouse brain as either puncta or axon-like structures. They appeared where infected neurons were undergoing apoptosis and Iba1-immunopositive microglia transformed themselves into macrophages. These results show, for the first time, that axonal injury, i.e., functional disturbance of the fast axonal transport, can take place during the course of acute viral encephalitis.