Cerebellar cognitive affective syndrome associated with topiramate
- 作者：Hanne Baillieux ; Werner Verslegers ; Philippe Paquier ; Peter P. De Deyn ; Peter Marië ; n
- 关键词：Topiramate ; Cognitive affective syndrome ; Epilepsy ; Cognition ; Behavior ; Cerebellum ; SPECT
- 刊名：Clinical Neurology and Neurosurgery
- 出版年：2008
- 期刊代码：60_03038467
- 类别：med
- 出版时间：May 2008
- 卷：110
- 期：5
- 页码：496-499
- 文件大小：145 K
摘要
The cerebellar cognitive affective syndrome (CCAS) represents a spectrum of cerebellar-induced neurocognitive and affective disturbances. In this report a patient is described who developed CCAS under a treatment with standard daily dose of the anti-epileptic drug topiramate (TPM). Cognitive disturbances consisted of impaired visuo-spatial memory, concentration deficits and executive dysfunctions. Behavior and affect were characterized by marked mood-swings and several disinhibited symptoms. After a gradual discontinuation of treatment with topiramate, a complete remission of the cognitive and affective symptoms was observed within 6 weeks. Functional neuroimaging studies by means of SPECT were conducted 2 weeks and 8 months following TPM discontinuation. This case report seems to suggest that functional disruption of the cerebello–cerebral circuitry, leading to CCAS, can follow treatment with topiramate.