- 作者：Toshiyuki Yasui ; Junko Tomita ; Yuka Miyatani ; Masayo Yamada ; Hirokazu Uemura ; Minoru Irahara ; Makoto Arai ; Noriko Kojimahara ; Ryugo Okabe ; Yasutomo Ishii ; Shin-ichi Tashiro ; Hiroshi Sato
- 关键词：Adiponectin ; SHBG ; Gender
- 刊名：Clinica Chimica Acta
- 出版年：2007
- 期刊代码：54_00098981
- 类别：med
- 出版时间：November-December 2007
- 卷：386
- 期：1-2
- 页码：69-75
- 文件大小：307 K
Methods
One hundred fifty-four men and 180 women aged from 50 to 85 years were included in the cross-sectional study. Serum concentrations of testosterone, estradiol, dehydroepiandrosterone-sulfate, SHBG and adiponectin were measured in men and women.
Results
Serum adiponectin concentration showed a significant positive correlation with serum SHBG concentration in men and women (r = 0.404, p < 0.0001 and r = 0.348, p < 0.0001, respectively). Multiple regression analysis also showed that SHBG was the significant predictor for adiponectin in men and women. Serum adiponectin concentration in men showed a significant positive correlation with total testosterone concentration, but that in women was not significantly correlated with total testosterone concentration. Both adiponectin and SHBG concentrations in men (r = − 0.222, p = 0.0051 and r = − 0.334, p < 0.0001, respectively) and women (r = − 0.281, p = 0.0014 and r = − 0.251, p = 0.0048, respectively) showed significant negative correlations with the homeostasis model assessment (HOMA) index.
Conclusion
Correlations between adiponectin and SHBG were significantly positive in both men and women, and both adiponectin and SHBG might be involved in insulin resistance in both sexes.