- 作者：Toshiyuki Yasui ; Masahiko Maegawa ; Junko Tomita ; Yuka Miyatani ; Masayo Yamada ; Hirokazu Uemura ; Shu-ichi Ueno ; Shusuke Numata ; Tetsuro Ohmori ; Naoko Tsuchiya ; Mitsutoshi Yuzurihara ; Shuichi Takeda ; M
- 关键词：Interleukin-6 ; Interleukin-8 ; Interleukin-10 ; Psychological symptoms ; Midlife women
- 刊名：Journal of Reproductive Immunology
- 出版年：2007
- 期刊代码：171_01650378
- 类别：med
- 出版时间：August 2007
- 卷：75
- 期：1
- 页码：56-62
- 文件大小：144 K
Methods
Fifty-three peri- and post-menopausal women with and without psychological symptoms in Greene's climacteric scale were enrolled in this study. Levels of 17 cytokines in serum samples were measured simultaneously using a multiplexed human cytokine assay.
Results
Serum interleukin (IL)-6 concentration in women with psychological symptoms (2.71 ± 047 pg/ml) was significantly (p = 0.009) higher than that in women without psychological symptoms (0.98 ± 0.18 pg/ml). Serum IL-8 concentration in women with psychological symptoms (33.4 ± 8.17 pg/ml) was also significantly (p = 0.022) higher than that in women without psychological symptoms (7.87 ± 1.64 pg/ml). In addition, serum IL-10 concentration in women with psychological symptoms (0.74 ± 0.26 pg/ml) was significantly (p = 0.048) higher than that in women without psychological symptoms (0.07 ± 0.04 pg/ml). Tumor necrosis factor (TNF)-α in serum was detected only in women with psychological symptoms. Serum IL-2 concentration in women with psychological symptoms tended (p = 0.066) to be higher than that in women without psychological symptoms. No significant differences were found between levels of other cytokines in women with and without psychological symptoms.
Conclusion
Psychological stress manifested as climacteric symptoms in midlife women may be associated with increases in serum concentrations of IL-6, IL-8, IL-10, and TNF-α.