A 15-day oral dose toxicity study of aspirin eugenol ester in Wistar rats

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• 作者：Jianyong Li^a ; ^{lijy1971@163.com} ; Yuanguang Yu^b ; Yajun Yang^a ; Xiwang Liu^a ; Jiyu Zhang^a ; Bing Li^a ; Xuzheng Zhou^a ; Jianrong Niu^a ; Xiaojuan Wei^a ; Zhiqi Liu^c
• 关键词：Aspirin eugenol ester (AEE) ; Subchronic toxicity ; Rats
• 刊名：Food and Chemical Toxicology
• 出版年：2012
• 期刊代码：20_02786915
• 类别：pha
• 出版时间：June, 2012
• 卷：50
• 期：6
• 页码：1980-1985
• 文件大小：949 K

摘要

The subchronic toxicity of aspirin eugenol ester (AEE) was evaluated after 15-day intragastrically administration in rats at daily doses of 50, 1000, and 2000 mg/kg. AEE at low-dose showed no toxicity to the tested rats. Following repeated exposure to medium- or high-dose of AEE, apparent changes were observed in the levels of blood glucose, AST, ALP, ALT and TB in both male and female rats, and appeared to be dose-independent. There were no significant gender differences in most indexes of subchronic toxicity throughout the experimental period with the exception of food consumption and body weight. The no-observed-adverse-effect level (NOAEL) of AEE was considered to be 50 mg/kg/day under the present study conditions.