- 作者：Osamu Kato ; Nami Kawasaki ; Daniel Bodri ; Tomoko Kuroda ; Satoshi Kawachiya ; Keiichi Kato ; Yuji Takehara ; y-takehara@towako-kato.com
- 关键词：Neonatal outcome ; Birth defects ; Cryopreservation ; Vitrification ; Minimal ovarian stimulation ; In vitro fertilization
- 刊名：European Journal of Obstetrics and Gynecology and Reproductive Biology
- 出版年：2012
- 期刊代码：92_03012115
- 类别：med
- 出版时间：March, 2012
- 卷：161
- 期：1
- 页码：46-50
- 文件大小：192 K
Objective
To compare neonatal outcome between children born after vitrified versus fresh single-embryo transfer (SET).Study design
Retrospective, single-centre cohort study of 6623 delivered singletons following 29,944 single-embryo transfers. Patients underwent minimal ovarian stimulation/natural cycle IVF followed by SET of fresh or vitrified-warmed (using Cryotop, Kitazato) cleavage-stage embryos or blastocysts. Outcome measures were gestational age at delivery, birth weight, birth length, low birth weight (LBW), small for gestational age (SGA) and large for gestational age (LGA) infants, perinatal mortality and minor/major birth defects (evaluated by parent questionnaire).
Results
Gestational age (38.6 卤 2 versus 38.7 卤 1.9 weeks) and preterm delivery rate (6.9%versus 6.9%, aOR: 0.96 95%CI: 0.76-1.22) in singletons born after the transfer of vitrified embryos were comparable to those born after the transfer of fresh embryos. Children born after the transfer of vitrified embryos had a higher birth weight (3028 卤 465 versus 2943 卤 470 g, p < 0.0001) and lower LBW (8.5%versus 11.9%, aOR: 0.65 95%CI: 0.53-0.79) and SGA (3.6%versus 7.6%aOR: 0.43 95%CI: 0.33-0.56) rates. Total birth defect rates (including minor anomalies) (2.4%versus 1.9%, aOR: 1.41 95%CI: 0.96-2.10) and perinatal mortality rates (0.6%versus 0.5%, aOR: 1.02 95%CI: 0.21-4.85) were comparable between the vitrified and fresh groups.
Conclusions
Vitrification of embryos/blastocysts did not increase the incidence of adverse neonatal outcomes or birth defects following single embryo transfer.