Antibacterial activity in serum of the 3,5-diamino-piperidine translation inhibitors
- 作者：Yuefen Zhou ; Chun Chow ; Douglas E. Murphy ; Zhongxiang Sun ; Thomas Bertolini ; Jamie M. Froelich ; Stephen E. Webber ; Thomas Hermann ; Daniel Wall
- 关键词：Aminoglycosides ; Antibiotics ; Translation inhibitors ; 2-Deoxy-streptamine ; Ribosome ; Decoding site ; 3 ; 5-Diamino-piperidine
- 刊名：Bioorganic and Medicinal Chemistry Letters
- 出版年：2008
- 期刊代码：10_0960894x
- 类别：ch
- 出版时间：1 June 2008
- 卷：18
- 期：11
- 页码：3369-3375
- 文件大小：167 K
摘要
Translation inhibitors of the 3,5-diamino-piperidine series act as aminoglycoside mimetics that inhibit bacterial growth. Here we show antibacterial SAR in the presence and absence of serum with a particular focus toward Pseudomonas aeruginosa.