Protecting confidentiality to safeguard adolescents' health: finding common ground

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• 作者：Scott J. Spear ; Abigail English
• 关键词：AEBSF ; Serine protease inhibitor ; Embryo ; Implantation
• 刊名：Contraception
• 出版年：2007
• 期刊代码：71_00107824
• 类别：med
• 出版时间：August 2007
• 卷：76
• 期：2
• 页码：73-76
• 文件大小：96 K

摘要

The study was conducted to investigate the inhibitory effect of 4-(2-aminoethyl)benzenesulfonyl fluoride hydrochloride (AEBSF) on embryo implantation in mice with a view to identifying whether it might be a suitable agent for postcoital contraception.

Study Design

The anti-implantation efficacy of AEBSF was determined by counting the number of visible implanted embryos on Day 8 of pregnancy following a single intrauterine injection of AEBSF at doses of 30, 300 and 3000 μg per mouse uterine horn on Day 3 of pregnancy. The reversibility of the inhibitory effect of AEBSF on implantation was further evaluated by observing the outcome of a subsequent pregnancy without AEBSF treatment.

Results

A dose-dependent inhibitory effect of AEBSF on embryo implantation in vivo was observed. Morphological analysis revealed no significant cytotoxicity of AEBSF on the mouse uterine epithelia. Furthermore, the anti-implantation effect of AEBSF was reversible.

Conclusion

Intrauterine administration of AEBSF at an appropriate dose might provide a basis for the development of novel contraception.