Impact of American College of Surgeons Oncology Group Z0011 and National Surgical Adjuvant Breast and Bowel Project B-32 trial results on surgeon practice in the Pacific Northwest

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• 作者：Kristen P. Massimino ; M.D.^a ; Crystal J. Hessman ; M.D.^a ; Michelle C. Ellis ; M.D.^a ; Arpana M. Naik ; M.D.^b ; John T. Vetto ; M.D.^b ; ^{vettoj@ohsu.edu}
• 关键词：American College of Surgeons Oncology Group Z0011 ; National Surgical Adjuvant Breast and Bowel Project B-32 ; Completion axillary dissection ; Immunohistochemistry ; survey
• 刊名：The American Journal of Surgery
• 出版年：2012
• 期刊代码：9_00029610
• 类别：med
• 出版时间：May, 2012
• 卷：203
• 期：5
• 页码：618-622
• 文件大小：227 K

摘要

Background

Recent clinical trials have suggested no survival benefit for completion axillary node dissection (CALND) after sentinel lymph node biopsy (American College of Surgeons Oncology Group Z0011) and no clinically meaningful benefit for the routine use of immunohistochemistry (National Surgical Adjuvant Breast and Bowel Project B-32) in clinically node-negative breast cancer.

Methods

A 12-question electronic survey was distributed to members of 3 Pacific Northwest surgical societies. Surgeons were queried regarding the impact of the trial results on their surgical management of breast cancer.

Results

The 181 respondents reported performing fewer CALNDs (63%), fewer intraoperative frozen sections (21%), and no immunohistochemistry (12%) because of trial data. However, 28%of surgeons continued to perform CALND in patients with 1 to 2 positive sentinel lymph nodes undergoing lumpectomy and postoperative radiation.

Conclusions

Recent trial data have impacted the performance of CALNDs and the pathological evaluation of sentinel lymph nodes among Pacific Northwest surgeons. Our results suggest a need for regional surgical societies to disseminate practice-changing trial data to members.