Efficient synthesis of kaempferol 3,7-O-bisglycosides via successive glycosylation with glycosyl ortho-alkynylbenzoates and trifluoroacetimidates

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• 作者：Weizhun Yang^a ; ^b ; Jiansong Sun^b ; ^{jssun@sioc.ac.cn} ; Zhongyi Yang^b ; Wei Han^a ; ; Wei-Dong Zhang^c ; Biao Yu^b ; ^{byu@mail.sioc.ac.cn}
• 关键词：Selective glycosylation ; Kaempferol ; Glycosyl ortho-alkynylbenzoate ; Glycosyl trifluoroacetimidate
• 刊名：Tetrahedron Letters
• 出版年：2012
• 期刊代码：109_00404039
• 类别：ch
• 出版时间：30 May, 2012
• 卷：53
• 期：22
• 页码：2773-2776
• 文件大小：474 K

摘要

Selective glycosylation of the 3-OH of 5,4鈥?di-O-acetyl-kaempferol was achieved with glycosyl ortho-alkynylbenzoates as donors under the catalysis of Ph₃PAuNTf₂, and subsequent glycosylation of the remaining 7-OH with glycosyl trifluoroacetimidates under the catalysis of BF₃路OEt₂, after global deprotection, afforded the kaempferol 3,7-O-bisglycosides conveniently.