• 作者：Montserrat Feijó ; o^a ; Isaac Tú ; nez^a ; ^{fm2tufii@uco.es} ; Adela Ruiz^b ; Inmaculada Tasset^a ; Elisa Muñ ; oz^b ; Eduardo Collantes^b
• 关键词：Artritis reumatoide ; Dañ ; o oxidativo ; Enfermedad articular inflamatoria cró ; nica ; Espondilitis anquilosante ; Especies reactivas del oxí ; geno
• 刊名：Reumatolog铆a Cl铆nica
• 出版年：2010
• 期刊代码：pca303_1699258X
• 类别：med
• 出版时间：March-April 2010
• 卷：6
• 期：2
• 页码：91-94
• 文件大小：150 K

Objective

To evaluate the participation of oxidative stress (OS) on chronic inflammatory joint disease (CIJD), as well as its possible use as a diagnostic biomarker.

Patients and methods

The study population comprised 29 patients with CIJD: 18 with rheumatoid arthritis (RA: 13 active/5 inactive); 11 with ankylosing spondylitis (AS: 7 active/4 inactive) and 13 healthy subjects. Activity of the disease was assessed by: RA patients, Disease Activity Score (DAS 28) and AS patients by means of Bath Ankylosing Spondylitis Disease Activity Index (BASDAI). Oxidative stress biomarkers were determined in plasma using spectrophotometrical techniques. The statistical analysis was carried out using the SSPS statistical package.

Results

Active CIJD showed a high oxidative stress characterized by increases in oxidative damage markers and a reduction in antioxidative systems, together with a higher myeloperoxidase (MPO) concentration. Inactive CIJD only showed changes in oxidized glutathione (GSSG) and reduced glutathione (GSH)/GSSG ratio levels, without changes in oxidative damage parameters or in antioxidative systems.

Conclusions

Our data revealed that: i) CIJD presents with a high oxidative stress; ii) inactive CIJD shows a production of reactive species without triggering oxidative damage and maintaining red-ox homeostasis, and iii) the combination of oxidative stress biomarkers may be used as markers of active-inactive stages of CIJD.