Remarkably fast and selective aromatization of Hantzsch esters with MoOCl₄ and MoCl₅: A chemical model for possible biologically relevant properties of molybdenum-containing enzymes

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• 作者：Mladen Litvi膰 ; ^{mladen.litvic@belupo.hr} ; ^{mlitvic@gmail.com} ; Maja Regovi膰 ; Karolina &Scaron ; mic ; Marija Lovri膰^&dagger ; ; Mirela Filipan-Litvi膰
• 关键词：1 ; 4-Dihydropyridines ; Aromatization ; Dealkylation ; Molybdenum pentachloride ; Molybdenum oxytetrachloride
• 刊名：Bioorganic and Medicinal Chemistry Letters
• 出版年：2012
• 期刊代码：10_0960894x
• 类别：ch
• 出版时间：1 June, 2012
• 卷：22
• 期：11
• 页码：3676-3681
• 文件大小：341 K

摘要

Mo(VI) and Mo(V) salts both react selectively with Hantzsch esters to produce substitute pyridines in good-to-excellent yield (75-99%). The remarkable reactivity and selectivity of MoOCl₄ under reflux of acetonitrile and MoCl₅ in dichloromethane at room temperature encouraged us to propose that molybdenum-containing enzymes (such as xanthine or aldehyde oxidase) also participate to some degree in the metabolism of 1,4-dihydropyridine drugs in the liver analogous to NADH in the respiratory chain.