Occurrence of aflatoxin M₁ and exposure assessment in Catalonia (Spain)

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• 作者：German Cano-Sancho ; Sonia Marin ; Antonio J. Ramos ; Juan Peris-Vicente ; Vicente Sanchis ; ^{vsanchis@tecal.udl.cat}
• 关键词：Aflatoxin M1 ; Exposure assessment ; Monte Carlo ; Probabilistic model ; Occurrence
• 刊名：Revista Iberoamericana de Micolog铆a
• 出版年：2010
• 期刊代码：pca320_11301406
• 类别：med
• 出版时间：July-September 2010
• 卷：27
• 期：3
• 页码：130-135
• 文件大小：149 K

摘要

Background

Aflatoxin M₁ (AFM₁) is the main monohydroxylated derivative of aflatoxin B₁ (AFB₁) formed in liver and excreted into milk. Although AFM₁ is less toxic than AFB₁, it has been classified as a possible human carcinogen, Group 2B agent by International Agency for Research on Cancer (IARC).

Objectives

The objectives of this study were (i) to determine the occurrence of AFM₁ in the main dairy products consumed in Catalonia region (Spain), and (ii) to assess the exposure of Catalonian population to aflatoxin M₁ through deterministic and probabilistic method.

Methods

Occurrence of Aflatoxin M₁ (AFM₁) was determined in 72 composites of milk, 72 composites of cheese and 72 composites of yoghurt from Catalonia. AFM₁ content was analysed using an Enzyme-Linked ImmunoSorbent Assay commercial kit. Three approaches to exposure assessment were conducted: one deterministic method and two probabilistic models with Monte Carlo simulations.

Results

AFM₁ was detected in 94.4%(68/72) of whole UHT milk samples, in 2.8%(2/72) of yoghurt samples and not detected in cheese. The maximum level was detected in one yoghurt sample with 51.58 ng/kg, only this sample being over the legal EU limit of 50 ng/kg. Milk, cheese and yoghurt mean concentrations were 9.29卤2.61, <12.5 and 13.22卤4.82 ng/kg, respectively.

Conclusions

According to these values, it should be expected Catalonian population is not exposed to a significant risk from aflatoxin M₁ including average and high consumers.