Early detection, prevention and management of cutaneous adverse events due to sorafenib: Recommendations from the Sorafenib Working Group

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• 作者：Sergio Bracarda^a ; ^{sergio.bracarda@usl8.toscana.it}  ; [Author Vitae] ; Enzo Maria Ruggeri^b  ; [Author Vitae] ; Marcello Monti^c  ; [Author Vitae] ; Marco Merlano^d  ; [Author Vitae] ; Alessandro D&rsquo ; Angelo^e  ; [Author Vitae] ; Francesco Ferra&ugrave ; ^e  ; [Author Vitae] ; Enrico Cortesi^f  ; [Author Vitae] ; Armando Santoro^g  ; [Author Vitae]
• 关键词：Sorafenib ; Cutaneous adverse events ; Hand-foot skin reaction ; Prevention ; Guidelines ; Targeted therapy
• 刊名：Critical Reviews in Oncology/Hematology
• 出版年：2012
• 期刊代码：73_10408428
• 类别：med
• 出版时间：June, 2012
• 卷：82
• 期：3
• 页码：378-386
• 文件大小：335 K

摘要

Cutaneous adverse events commonly reported with tyrosine kinase inhibitors (TKIs) in the treatment of malignancies, represent an important clinical concern since they can limit the optimal use of these novel drugs. Although there are numerous reports in the literature of these events there are no practical guidelines on how they should be managed. The Sorafenib Working Group (SWG) was established with the objective of developing recommendations to allow the early detection, prevention and management of cutaneous adverse events in everyday clinical practice. The SWG was a multidisciplinary team made up of experts in the field who were closely involved in the sorafenib clinical development program. This review provides an overview of the nature and incidence of cutaneous adverse events which manifest with sorafenib treatment and provides recommendations for their early detection and effective management in clinical practice.