Alterations of T-lymphocyte populations in Parkinson disease

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• 作者：Yasuhiko Baba ; Ataru Kuroiwa ; Ryan J. Uitti ; Zbigniew K. Wszolek and Tatsuo Yamada
• 关键词：Cytokine ; Immunologic alteration ; Parkinson disease ; T lymphocyte
• 刊名：Parkinsonism and Related Disorders
• 出版年：2005
• 期刊代码：215_13538020
• 类别：med
• 出版时间：December 2005
• 卷：11
• 期：8
• 页码：493-498
• 文件大小：204 K

摘要

Immune reaction-related inflammation may be important in the pathogenesis of Parkinson disease (PD). To elucidate peripheral immunologic alterations in PD, we characterized extended peripheral T-lymphocyte populations in 33 patients with PD and 34 normal subjects. Patients with PD had significantly decreased CD4⁺:CD8⁺T-cell ratios (P<0.001), fewer CD4⁺CD25⁺T cells (P<0.01), and significantly increased ratios of IFN-γ-producing to IL-4-producing T cells (P<0.001). The characteristics of predominant expression of CD8⁺T cells, depletion of CD4⁺CD25^high cells, and a shift to a T_H1-type immune response in the peripheral immune system in PD patients may reflect an immune reaction-associated inflammatory process in the brain.