Fetal thyroid in two-dimensional ultrasonography: nomograms according to gestational age and biparietal diameter

详细信息	查看全文 | 推荐本文 |

• 作者：Ma艂gorzata Gietka-Czernel^a ; ^{malgietka@vp.pl} ; Marzena D臋bska^b ; Piotr Kretowicz^b ; Romuald D臋bski^b ; Wojciech Zgliczy艅ski^a
• 关键词：Maternal Graves&rsquo ; disease ; Fetal goiter ; Ultrasonography
• 刊名：European Journal of Obstetrics and Gynecology and Reproductive Biology
• 出版年：2012
• 期刊代码：92_03012115
• 类别：med
• 出版时间：June, 2012
• 卷：162
• 期：2
• 页码：131-138
• 文件大小：1065 K

摘要

Objective

To establish fetal thyroid nomograms based on gestational age and biparietal diameter and to compare obtained results with previously published data.

Study design

A cross-sectional study of 241 healthy pregnant women at 14-38 week of gestation was undertaken. Exclusion criteria were: known maternal thyroid or systemic disease, unknown date of last menstrual period, multiple pregnancy and fetal malformations. Fetal thyroid diameter (FTD), circumference (FTC) and area (FTA) were measured by two-dimensional ultrasonography and plotted against gestational age (GA) and biparietal diameter (BPD).

Results

FTD, FTC and FTA increased logarithmically to GA and BPD. Fetal thyroid measurements as a function of GA were expressed by logarithmic formulas: ln(FTD) = 3.6025-23.0315/GA, ln(FTC) = 4.6227-22.8003/GA, ln(FTA) = 6.6303-45.0831/GA. The following logarithmic formulas were obtained for fetal thyroid measurements according to BPD: ln(FTD) = 3.4068-45.4271/BPD, ln(FTC) = 4.4271-44.8359/BPD, ln(FTA) = 6.2390-88.4408/BPD. There were highly significant correlations between thyroid measurements and GA or BPD: r = 0.87-0.90, p < 0.00001.

Conclusions

We have established age-dependent and age-independent nomograms of fetal thyroid. These nomograms will enable prenatal diagnosis in fetuses at risk of thyroid disorders.