4-Acylamino-and 4-ureidobenzamides as melanin-concentrating hormone (MCH) receptor 1 antagonists

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• 作者：Receveur ; Jean-Marie ; Bjurling ; Emelie ; Ulven ; Trond ; Little ; Paul Brian ; N脙脙rregaard ; Pia K. ; et. al.
• 关键词：Melanin-concentrating hormone receptor 1 ; MCH1 ; MCH1 receptor ; MCH1 receptor antagonists ; Structure脙脙脙脙脙脙activity relationships ; Benzamides
• 刊名：Bioorganic and Medicinal Chemistry Letters
• 出版年：2004
• 期刊代码：10_0960894x
• 类别：ch
• 出版时间：October 18, 2004
• 卷：14
• 期：20
• 页码：5075-5080
• 文件大小：301 K

摘要

Synthesis, in vitro biological evaluation and structure芒芒芒activity relationships of 4-acylamino-and 4-ureidobenzamides as novel hMCH1R-antagonists are disclosed. The nature of the amine side chains could be varied considerably in contrast to the central benzamide scaffold and aromatic substituents.