NF-κB Inhibition Enhances Peroxynitrite-Induced Enterocyte Apoptosis

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• 作者：Potoka ; Douglas A. ; Upperman ; Jeffrey S. ; Nadler ; Evan P. ; Wong ; Catarina T. ; Zhou ; Xin ; Zhang ; Xiao-Ru ; et. al.
• 刊名：Journal of Surgical Research
• 出版年：2002
• 期刊代码：299_00224804
• 类别：med
• 出版时间：July, 2002
• 卷：106
• 期：1
• 页码：7-14
• 文件大小：235 K

摘要

Background. Sustained overproduction of nitric oxide and peroxynitrite (ONOO^−) in conditions such as necrotizing enterocolitis and inflammatory bowel disease may promote gut barrier failure by inducing enterocyte apoptosis. NF-κB is upregulated in the gut during inflammation and, in addition to its proinflammatory effects, may upregulate protective or antiapoptotic factors such as inhibitor of apoptosis proteins (IAPs). We have previously demonstrated that NF-κB inhibition increases cytokine-induced enterocyte apoptosis; however, the effect of NF-κB on ONOO^−-induced enterocyte apoptosis is unknown.