Histopathologic changes in the uterus, cervix and vagina of immature CD-1 mice exposed to low doses of perfluorooctanoic acid (PFOA) in a uterotrophic assay

详细信息	查看全文 | 推荐本文 |

• 作者：Darlene Dixon^a ; ^{dixon@niehs.nih.gov} ; Casey E. Reed^a ; Alicia B. Moore^a ; Eugene A. Gibbs-Flournoy^b ; Erin P. Hines^c ; Elizabeth A. Wallace^a ; Jason P. Stanko^a ; Yi Lu^d ; Wendy N. Jefferson^e ; Retha R. Newbold^f ; Suzanne E. Fenton^a ; ^{fentonse@niehs.nih.gov}
• 关键词：PFOA ; Immature mice ; Uterotrophic assay ; Uterus ; Cervix ; Vagina ; Pathology ; Estradiol
• 刊名：Reproductive Toxicology
• 出版年：2012
• 期刊代码：233_08906238
• 类别：med
• 出版时间：July, 2012
• 卷：33
• 期：4
• 页码：506-512
• 文件大小：1383 K

摘要

The estrogenic and antiestrogenic potential of perfluorooctanoic acid (PFOA) was assessed using an immature mouse uterotrophic assay and by histologic evaluation of the uterus, cervix and vagina following treatment. Female offspring of CD-1 dams were weaned at 18 days old and assigned to groups of equal weight, and received 0, 0.01, 0.1, or 1 mg PFOA/kg BW/d by gavage with or without 17-尾 estradiol (E₂, 500 渭g/kg/d) from PND 18-20 (n = 8/treatment/block). At 24 h after the third dose (PND 21), uteri were removed and weighed. Absolute and relative uterine weights were significantly increased in the 0.01 mg/kg PFOA only group. Characteristic estrogenic changes were present in all E₂-treated mice; however, they were minimally visible in the 0.01 PFOA only mice. These data suggest that at a low dose PFOA produces minimal histopathologic changes in the reproductive tract of immature female mice, and does not antagonize the histopathologic effects of E₂.