Evaluating the effectiveness of conjugated pneumococcal vaccines in Colombia
- 作者：N.I. Manjarres-Posada ; L.A. Choconta-Piraquive ; F. De la Hoz-Restrepo
- 关键词：Streptococcus pneumoniae ; Pneumococcal Infections ; Pneumococcal Vaccines ; Vaccine effectiveness
- 刊名：Procedia in Vaccinology
- 出版年：2012
- 期刊代码：P112_1877282x
- 类别：med
- 出版时间：2012
- 卷：6
- 期：Complete
- 页码：150-155
- 文件大小：239 K
摘要
A retrospective cohort study was conducted in 2631 Colombian children <2 yrs to evaluate pneumococcal vaccine effectiveness. Association between vaccination and disease was evaluated using Cox proportional hazards models. Vaccinated children had a significant reduction in hospitalization risk for all outcomes (HR 0,59 CI 95%0,42 - 0,85) and for pneumonia the reduction was slightly higher (HR 0,53 CI 95%0,32 - 0,89). Our results show an important risk reduction in clinical syndromes potentially associated to pneumococcus in vaccinated children confirming the benefits of using conjugate vaccines in a medium income developing country.