Synthesis and characterization of novel tetrahedral copper(I) complexes comprising tridentate PNP-aminodiphosphines and tetradentate PN(X)P-substituted aminodiphosphines (X = O, S)

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• 作者：Valentina Peruzzo^a ; Cornelia Pretzsch^b ; Francesco Tisato^a ; ^{tisato@icis.cnr.it} ; Marina Porchia^a ; Fiorenzo Refosco^a ; Cristina Marzano^c ; Valentina Gandin^c ; Eik Schiller^d ; Martin Walther^b ; Hans-Jü ; rgen Pietzsch^b
• 关键词：Aminodiphosphines ; Copper(I) complexes ; Cytotoxic activity ; Polydentate phosphines ; Phosphorus NMR
• 刊名：Inorganica Chimica Acta
• 出版年：2012
• 期刊代码：40_00201693
• 类别：ch
• 出版时间：30 May, 2012
• 卷：387
• 期：Complete
• 页码：163-172
• 文件大小：768 K

摘要

Two series of novel tetrahedral copper(I) complexes comprising tridentate PNP-aminodiphosphines and tetradentate PN(X)P-substituted aminodiphosphines (X = O, S) have been prepared and characterized by conventional physico-chemical techniques. The first series includes 鈥? + 1鈥?type complexes comprising an aromatic PNP-aminodiphosphine and acetonitrile or triphenylphosphine. In the second series, the central amine function of the PNP-ligand was substituted with functionalized pendant arms containing ether, hydroxyl or thioether groups to enhance the chelation ability of the ligand. Fully coordinated neutral and cationic complexes were isolated. A preliminary study investigating both the labeling of ⁶⁴Cu with the prototype PN(S)P ligand and the potential cytotoxic activity of the 鈥榗old鈥?[Cu(PN(S)P)][BF₄] complex is reported.