Plant VDAC: Facts and speculations
- 作者：Fabrice Homblé ; ; fhomble@ulb.ac.be ; Eva-Maria Krammer ; Martine Pré ; vost
- 关键词：ATR-FTIR ; attenuated total reflection Fourier transform infrared spectroscopy ; AtVDAC ; Arabidopsis thaliana VDAC ; CD ; circular dichroism spectroscopy ; GmVDAC ; Glycine max VDAC ; hVDAC1 ; human VDAC1 ; LjVDAC ; Lotus japonicus VDAC ; MIM ; mitochondrial inner me
- 刊名：Biochimica et Biophysica Acta (BBA)/Biomembranes
- 出版年：2012
- 期刊代码：14_00052736
- 类别：bio
- 出版时间：June, 2012
- 卷：1818
- 期：6
- 页码：1486-1501
- 文件大小：3233 K
摘要
The voltage-dependent anion-selective channel (VDAC) is the most abundant protein in the mitochondrial outer membrane and the major transport pathway for a large variety of compounds ranging from ions to large polymeric molecules such as DNA and tRNA. Plant VDACs feature a secondary structure content and electrophysiological properties akin to those of VDACs from other organisms. They however undergo a specific regulation. The general importance of VDAC in plant physiology has only recently emerged. Besides their role in metabolite transport, plant VDACs are also involved in the programmed cell death triggered in response to biotic and abiotic stresses. Moreover, their colocalization in non-mitochondrial membranes suggests a diversity of function. This review summarizes our current understanding of the structure and function of plant VDACs. This article is part of a Special Issue entitled: VDAC structure, function, and regulation of mitochondrial metabolism.