We quantify here the risk factors of influenza transmission in households from a prospective study conducted in the 1999–2000 winter season in France. Two hundred seventy-nine households were enrolled in the study, where a member—the index case—visited his/her general practitioner for influenza-like illness and tested positive for influenza A/H3N2. A standardized daily questionnaire allowed for identification of secondary cases of clinical influenza among the 543 contacts followed up for 15 days.