Bioactive alkenylphenols from Piper obliquum

详细信息	查看全文 | 推荐本文 |

• 作者：Carola Valdivia ; Nieves Marquez ; John Eriksson ; Antonio Vilaseca ; Eduardo Mu&#xf1 ; oz ; Olov Sterner
• 关键词：Piper obliquum ; Alkenylphenols ; Obliquol A and B ; Structure determination ; Synthesis ; Antibacterial ; Anti-inflammatory
• 刊名：Bioorganic and Medicinal Chemistry
• 出版年：2008
• 期刊代码：9_09680896
• 类别：ch
• 出版时间：1 April 2008
• 卷：16
• 期：7
• 页码：4120-4126
• 文件大小：199 K

摘要

Various parts of Piper obliquum Ruíz & Pavon yielded the new alkenylphenols obliquol A (1) and obliquol B (2), the new 4-chromanone 3 together with the known compounds 4 and 5. A synthesis of obliquol B (2) was developed in order to confirm its structure and to provide sufficient amounts for biological testing. Compounds 1 and 2 have antibacterial activity comparable to that of ampicillin, 2 in addition possesses potent anti-NF-κB activity by targeting early events in the TNFf" alt="greek small letter alpha" title="greek small letter alpha" border="0">-induced NF-κB inflammatory pathway, which may explain the effects reported for the traditional use of the plant.