A CBS haplotype and a polymorphism at the MSR gene are associated with cardiovascular disease in a Spanish case–control study

详细信息	查看全文 | 推荐本文 |

• 作者：Roser Urreizti ; Carla Asteggiano ; Maria Antonia Vilaseca ; Emili Corbella ; Xavier Pint&#xf3 ; Daniel Grinberg ; Susana Balcells
• 关键词：CBS ; SNP ; Haplotype ; CAD ; Assocaition
• 刊名：Clinical Biochemistry
• 出版年：2007
• 期刊代码：55_00099120
• 类别：med
• 出版时间：August 2007
• 卷：40
• 期：12
• 页码：864-868
• 文件大小：146 K

摘要

The aim of this study was to evaluate the association of polymorphisms present in genes related to homocysteine (Hcy) metabolism with coronary artery disease (CAD).

Design and methods:

We examined 8 polymorphisms in the cystathionine β-synthase (CBS), glutamate carboxypeptidase II (GCPII), methionine synthase (MS), methionine synthase reductase (MSR) and methylenetetrahydrofolate reductase (MTHFR) genes in 140 CAD patients and 113 controls, by means of Chi-square, logistic regression, ANOVA and the Mann–Whitney U test.

Results:

The c.66 G allele of MSR conferred an odds-ratio for CAD of 1.76 (95%CI 1.12–2.77), while a CBS haplotype [c.699C–c.844wt–c.1080C] was found over-represented in CAD [OR of 2.16 (1.29–3.63)].

Conclusions:

Our results not only highlight the involvement of the MSR and CBS genes in the etiology of cardiovascular disease, but also emphasize the strength of haplotype analyses in association studies.