The purpose of this prospective study was to assess the diagnostic accuracy of phi and PCA3 for prostate cancer using biopsy as gold standard.
Phi index (Beckman coulter immunoassay), PCA3 score (Progensa PCA3 assay) and other established biomarkers (tPSA, fPSA and%fPSA) were assessed before a 18-core prostate biopsy in a group of 251 subjects at their first biopsy.
Values of%p2PSA and phi were significantly higher in patients with PCa compared with PCa-negative group (p < 0.001) and also compared with high grade prostatic intraepithelial neoplasia (HGPIN) (p < 0.001). PCA3 score values were significantly higher in PCa compared with PCa-negative subjects (p < 0.001) and in HGPIN vs PCa-negative patients (p < 0.001). ROC curve analysis showed that%p2PSA, phi and PCA3 are predictive of malignancy.
In conclusion,%p2PSA, phi and PCA3 may predict a diagnosis of PCa in men undergoing their first prostate biopsy. PCA3 score is more useful in discriminating between HGPIN and non-cancer.