Influenza virosomes enhance class I restricted CTL induction through CD4+ T cell activation

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• 作者：Schumacher ; Reto ; Adamina ; Michel ; Zurbriggen ; Rinaldo ; Bolli ; Martin ; Padovan ; Elisabetta ; et. al.
• 关键词：Virosomes ; CTL ; Adjuvance ; T-helper 1
• 刊名：Vaccine
• 出版年：2004
• 期刊代码：89_0264410x
• 类别：imm
• 出版时间：January 26, 2004
• 卷：22
• 期：5-6
• 页码：715-724
• 文件大小：298 K

摘要

Immunopotentiating reconstituted influenza virosomes (IRIV) are one of the few adjuvants currently licensed for human use. While their adjuvant capacity in the induction of humoral responses is clearly documented, few data exist on their effects on T cell immune response. Here we addressed IRIV adjuvance in the induction of HLA class I restricted cytotoxic T lymphocytes (CTL) in vitro.