Anti-angiogenetic effects of immune-reconstituted influenza virosomes assembled with parathyroid hormone-related protein derived peptide vaccine
- 作者：Pierpaolo Correale ; Maria Teresa Del Vecchio ; Tommaso Renieri ; Giuseppa Di Genova ; Marco La Placa ; Cinzia Remondo ; Gianni Gori Savellini ; Chiara Terrosi ; Rinaldo Zurbriggen ; Mario Amacker ; Guido Franc
- 关键词：PTH-rP ; IRIV ; Cancer vaccine ; Angiogenesis ; Immunotherapy
- 刊名：Cancer Letters
- 出版年：2008
- 期刊代码：44_03043835
- 类别：med
- 出版时间：18 May 2008
- 卷：263
- 期：2
- 页码：291-301
- 文件大小：1111 K
摘要
C-IRIV/PTR-4 is a novel anticancer vaccine construct composed of immune-reconstituted influenza virosomes (IRIV) assembled with the PTH-rP derived peptide (PTR)-4, a synthetic CTL epitope with HLA-A(*)02.01 amino acid binding motifs. This peptide is able to generate a human PTH-rP specific CTL response with anti-tumor activity in vitro and in mice.