Virosome: A novel vector to enable multi-modal strategies for cancer therapy
- 作者：Yasufumi Kaneda ; kaneday@gts.med.osaka-u.ac.jp
- 关键词：Pseudovirion ; Synthetic vector ; Virus ; Anti-tumor immunity ; Apoptosis ; RNA ; Fusion protein
- 刊名：Advanced Drug Delivery Reviews
- 出版年：2012
- 期刊代码：2_0169409x
- 类别：bio
- 出版时间：1 June, 2012
- 卷：64
- 期：8
- 页码：730-738
- 文件大小：532 K
摘要
Despite advancements in treatments, cancer remains a life-threatening disease that is resistant to therapy. Single-modal cancer therapy is often insufficient to provide complete remission. A revolution in cancer therapy may someday be provided by vector-based gene and drug delivery systems. However, it remains difficult to achieve this aim because viral and non-viral vectors have their own advantages and limitations. To overcome these limitations, virosomes have been constructed by combining viral components with non-viral vectors or by using pseudovirions without viral genome replication. Viruses, such as influenza virus, HVJ (hemagglutinating virus of Japan; Sendai virus) and hepatitis B virus, have been used in the construction of virosomes. The HVJ-derived vector is particularly promising due to its highly efficient delivery of DNA, siRNA, proteins and anti-cancer drugs. Furthermore, the HVJ envelope (HVJ-E) vector has intrinsic anti-tumor activities including the activation of multiple anti-tumor immunities and the induction of cancer-selective apoptosis. HVJ-E is currently being clinically used for the treatment of melanoma. A promising multi-modal cancer therapy will be achieved when virosomes with intrinsic anti-tumor activities are utilized as vectors for the delivery of anti-tumor drugs and genes.