Purpose: Tenascin-C (Tn-C) is an extracellular matrix glycoprotein expressed transiently in areas of epithelial-mesenchymal interaction during embryogenesis and neoplasia. Our previous work showed an association between metastasis and Tn-C expressed in invasion border of axillary node-negative breast carcinomas. Our aim was to relate this Tn-C expression with several histopathological and biological variables and to compare their usefulness to predict recurrences.