Phylogenetic analysis of foot-and-mouth disease virus type O re-emerging in free areas of South America

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• 作者：Viviana Malirat ; José ; Jú ; nior Franç ; a de Barros ; Ingrid Evelyn Bergmann ; Renata de Mendonç ; a Campos ; Erika Neitzert ; Eliane Veiga da Costa ; Edson Elias da Silva ; Abraham Jaime Falczuk
• 关键词：Foot-and-mouth disease virus ; Molecular epidemiology ; Sequence analysis ; Europe– ; South America FMDV topotype
• 刊名：Virus Research
• 出版年：2007
• 期刊代码：92_01681702
• 类别：imm
• 出版时间：March 2007
• 卷：124
• 期：1-2
• 页码：22-28
• 文件大小：469 K

摘要

The nucleotide sequences of the complete VP₁-coding region of foot-and-mouth disease viruses (FMDV), type O, isolated during the recent emergencies of the disease in free areas of South America (Mato Grosso do Sul, Brazil, October 2005, and Corrientes, Argentina, February 2006), were determined. Also established were the complete VP₁-coding sequences of viruses occurring in neighbouring locations between the years 2000 and 2003. A phylogenetic analysis was performed based on comparison with continental relevant field and vaccine strains, as well as with extra-continental representative viruses.

The results show that the emergencies in Argentina and Brazil were caused by viruses presenting 93%genetic relatedness. Both variants are endogenous to South America, as they were placed within the Europe–South America topotype. When compared with the continental viruses available for the phylogenetic studies, they show the closest relationship with viruses responsible for previous emergencies in neighbouring free areas, or for sporadic outbreaks in the adjacent places with advanced eradication stages, presenting similarity values of at least 90%among them, and clustering together in a unique lineage. This lineage represents the only one sporadically appearing in the Southern Cone and differs from those including viruses presently circulating in the Andean region, reflecting the different livestock circuits and epidemiological scenarios.