Gene-environment interactions between smoking and a haplotype of RAI, ASE-1 and ERCC1 polymorphisms among women in relation to risk of lung cancer in a population-based study

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• 作者：Ulla Vogel ; Mette Sø ; rensen ; Rikke Dalgaard Hansen ; Anne Tjø ; nnel ; Kim Overvad ; Hå ; kan Wallin ; Bjø ; rn A. Nexø ; ; Ole Raaschou-Nielsen
• 关键词：Apoptosis ; Lung cancer ; Population-based ; SNPs
• 刊名：Cancer Letters
• 出版年：2007
• 期刊代码：44_03043835
• 类别：med
• 出版时间：8 March 2007
• 卷：247
• 期：1
• 页码：159-165
• 文件大小：108 K

摘要

Homozygous carriers of a haplotype consisting of ERCC1 Asn118Asn^A, ASE-1 G-21A^G, RAI IVS1 A4364G^A are at increased risk of lung cancer especially among women.

Here, we analyse for gene-environment interactions with the predefined haplotype in a case cohort study including 428 lung cancer cases and a comparison group of 800 persons, all from the prospective Diet, Cancer and Health cohort of 57,000 Danes.

At high smoking intensity (>20 g tobacco/day), there was only additional risk of smoking intensity among women who were homozygous carriers of the haplotype (IRR=2.03; 95%CI: 1.10–3.73 per 5 additional g tobacco/day).