Calculating the time to extinction of a reactivating virus, in particular bovine herpes virus

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作者：A.A. de Koeijer ; O. Diekmann ; M.C.M. de Jong
关键词：Reactivating infection ; Bovine herpes virus ; Extinction
刊名：Mathematical Biosciences
出版年：2008
期刊代码：40_00255564
类别：mt
出版时间：April 2008
卷：212
期：2
页码：111-131
文件大小：533 K

摘要

On a examiné par l'analyse de la restrictase huit souches bulgares de virus herpès bovins, deux souches hongroises de virus herpès (1A et 3A), l'une isolée d'un buffle 723, l'autre isolée d'un veau nommé ‘Mramor’ et deux souches de virus de référence BHVI. Le profil migratoire des virus a été comparé à l'aide d'enzymes restrictase Hpa I, BamH I, Hind III. Une nette différence a été constatée entre les deux souches hongroises, la souche isolée du veau ‘Mramor’, celle isolée du buffle 723 et les huit souches bulgares. La souche Sartze a été déterminéee comme type génital, alors que Ozet, Tch.voda, Slivnitza, B. Budinov, Ptcelarovo, Vrana, Podgumer sont des types respiratoires. Le deux virus hongrois 1A et 3A, la souche isolée du veau ‘Mramor’, et celle isolée du buffle 723 ont un profil migratoire comparable à celui des virus herpès du porc. Après Soutchern blotting, une hybridation entre fragment K 22 et les huit virus herpès bovins a été constatée. Il y a une liaison génétique entre ces souches. Il n'y a pas d'hybridation entre les souches hongroises 1A et 3A, celle isolée du veau Mramor et celle isoléee du buffle 723. Cette observation nous permet de conclure que les souches sont génétiquement différentes de BHV 1.

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border=0 src="/scidirimg/jrn_nsub.gif" alt="You are not entitled to access the full text of this document" title="You are not entitled to access the full text of this document" width=12 height=14"> b=ArticleURL&_udi=B6TD6-476VJX9-R8&_user=10&_coverDate=02%2F28%2F1994&_rdoc=1&_fmt=high&_orig=article&_cdi=5190&_sort=v&_docanchor=&view=c&_ct=820&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=7076772274e931e50b5eec112389b745">Immediatebr>-br>early gene expression and gene mapping comparisons among isolates of bovine herpesvirus 1 and 5b> Veterinary Microbiology, Volume 38, Issue 4, February 1994, Pages 369-384 Bruce S. Seal, Cecelia A. Whetstone Abstractb>

Bovine herpesviruses (BHV) are associated with a variety of clinical syndromes. Bovine herpesvirus 1 isolates were placed into three genome subtypes based on restriction endonuclease analyses, which were loosely associated by clinical manifestation as BHV1.1 (respiratory), BHV1.2 (genital), and BHV1.3 (encephalitic). More recently the encephalitic isolate has been classified BHV5. A comparison of the cytopathic effect (CPE) in fetal bovine lung cell cultures in the presence of cycloheximide showed that BHV1.1 and 1.2 isolates produced elongated, spindle-shaped CPE, whereas BHV5 produced more syncytial-like CPE. Each BHV-1 subtype synthesized four immediate-early transcripts. The sizes in kb were: 1.6, 3.4, 5.8, 7.5 (BHV1.1); 1.8, 3.6, 5.8, 7.5 (BHV1.2); and 1.8, 3.6, 5.8, 8.6 (BHV5). These transcripts were mapped to the inverted repeat region of each islate by Southern blot hybridization using cDNA prepared from cycloheximide-treated BHV1-infected cellular polyA RNA. A possible unique immediate-early RNA may be produced by the BHV5 encephalitic isolate from an area of the internal repeat region unique to this isolate. Hybridization analysis using BHV1.1 cloned probes of the immediate-early protein gene, thymidine kinase gene, DNA binding/DNA polymerase gene, and glycoprotein III gene provided information for mapping of these genes to the BHV5 encephalitic isolate.

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