Vaginal allergic response in women with vulvovaginal candidiasis
- 作者：S.R. Fan ; Q.P. Liao ; X.P. Liu ; Z.H. Liu ; D. Zhang
- 关键词：Allergic response ; Chemokines ; Cytokines ; Immunoglobulin ; Vulvovaginal candidiasis
- 刊名：International Journal of Gynecology and Obstetrics
- 出版年：2008
- 期刊代码：130_00207292
- 类别：med
- 出版时间：April 2008
- 卷：101
- 期：1
- 页码：27-30
- 文件大小：127 K
摘要
Objective: To determine the concentration of certain cytokines and immunoglobulin (Ig) E in the vaginal lavage fluid (VLF) of women with vulvovaginal candidiasis (VVC). Method: Cytokin and IgE concentrations were measured in the VLF of women with VVC; women free of any genital infections acted as controls. Result: The VLF concentrations of interleukin (IL)-2, IL-8, and interferon (INF)-γ were higher among women with VVC than in the control group; women with severe VVC had a higher VLF concentration of IL-4 than those with mild to moderate VVC; women with cured VVC had a higher VLF concentration of IL-13 than did controls; and women with VVC or cured VVC had a higher VLF concentration of IgE than did controls (P < 0.05 for all). Conclusion: Both helper T cells type 1 and innate response cytokines were shown to play a dominant role in the pathogenesis of VVC. This allergic vaginal response in women with VVC suggests that the form of treatment for VVC should be reconsidered.