摘要
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Aim
To investigate the metabolic characteristics of the temporal lobes following radiation therapy for nasopharyngeal carcinoma using diffusion tensor imaging (DTI) and proton magnetic resonance spectroscopy (p>1p>H-MRS).Materials and methods
<p>DTI and p>1p>H-MRS were performed in 48 patients after radiotherapy for nasopharyngeal carcinoma and in 24 healthy, age-matched controls. All patients and controls had normal findings on conventional MRI. Apparent diffusion coefficient (ADC), fractional anisotropy (FA), three eigenvalues 位1, 位2, 位3, N-acetylaspartic acid (NAA)/choline (Cho), NAA/creatinine (Cr), and Cho/Cr were measured in both temporal lobes. Patients were divided into three groups according to time after completion of radiotherapy: group 1, less than 6 months; group 2, 6-12 months; group 3, more than 12 months. Mean values for each parameter were compared using one-way analysis of variance (ANOVA).Results
<p>Mean FA in group 1 was significantly lower compared to group 3 and the control group (p聽<聽0.05). Group-wise comparisons of apparent diffusion coefficient (ADC) values among all the groups were not significantly different. Eigenvalue 位1 was significantly lower in groups 1 and 3 compared to the control group (p聽<聽0.05). NAA/Cho and NAA/Cr were significantly lower in each group compared to the control group (p聽<聽0.01 for both). The decrease in NAA/Cho was greatest in group 1. There were no significant between-group differences regarding Cho/Cr.Conclusion
<p>A combination of DTI and p>1p>H-MRS can be used to detect radiation-induced brain injury, in patients treated for nasopharyngeal carcinoma.